# Optical Sensor System for 3D Jones Matrix Reconstruction of Optical Anisotropy Maps of Self-Assembled Polycrystalline Soft Matter Films

## TL;DR

This paper introduces a new optical sensor system to reconstruct 3D Jones matrix maps of dehydrated biofluid films for detecting pathological changes.

## Contribution

A novel 3D polarization scanning technique for analyzing optical anisotropy in dehydrated biofluid films is developed and validated.

## Key findings

- The method correlates Jones matrix images with birefringence in blood plasma and saliva films from healthy and diseased individuals.
- Statistical moments of 1st to 4th order are most sensitive to structural changes in dehydrated biofluid films.
- The technique shows potential for diagnosing endometriosis through optical analysis of biofluid film structures.

## Abstract

Our work uses a polarization matrix formalism to analyze and algorithmically represent optical anisotropy by open dehydration of blood plasma films. Analytical relations for Jones matrix reconstruction of optical birefringence maps of protein crystal networks of dehydrated biofluid films are found. A technique for 3D step-by-step measurement of the distributions of the elements of the Jones matrix or Jones matrix images (JMI) of the optically birefringent structure of blood plasma films (BPF) has been created. Correlation between JMI maps and corresponding birefringence images of dehydrated BPF and saliva films (SF) obtained from donors and prostate cancer patients was determined. Within the framework of statistical analysis of layer-by-layer optical birefringence maps, the parameters most sensitive to pathological changes in the structure of dehydrated films were found to be the central statistical moments of the 1st to 4th orders. We physically substantiated and experimentally determined the sensitivity of the method of 3D polarization scanning technique of BPF and SF preparations in the diagnosis of endometriosis of uterine tissue.