# Delayed Presentation of Malignancy-Associated Pseudoachalasia of the Gastric Cardia

**Authors:** Clive J Miranda, Farhan Azad, Ross R Moyer, Sasikanth N Ravi, Gina M Sparacino

PMC · DOI: 10.7759/cureus.54040 · Cureus · 2024-02-11

## TL;DR

This paper presents a case where a cancer-related condition mimicked achalasia, highlighting the need for timely endoscopy to detect underlying malignancies.

## Contribution

The paper emphasizes the importance of early endoscopic evaluation in pseudoachalasia to identify malignancies.

## Key findings

- A 65-year-old patient with pseudoachalasia was later diagnosed with gastric cardia adenocarcinoma.
- Timely esophagogastroduodenoscopy is critical to distinguish pseudoachalasia from primary achalasia.
- Diagnostic delays can occur due to nonspecific symptoms and imaging results in malignant pseudoachalasia.

## Abstract

Pseudoachalasia is a condition in which symptoms, manometry, and imaging findings highly resemble primary achalasia but has a secondary etiology. The majority of patients with pseudoachalasia have the condition as the result of a malignancy, most often at the gastroesophageal junction. There may be issues with timely identification of this malignancy as symptoms are often obscure with diagnostic testing yielding nonspecific results. We describe a case of a 65-year-old diabetic female smoker with a four-month history of intractable vomiting, abdominal pain, and weight loss who was belatedly found to have an adenocarcinoma at the gastric cardia necessitating a total gastrectomy and chemotherapy administration. The case educates clinicians on the clinical alarm symptoms related to malignant pseudoachalasia and stresses the paramount importance of performing a timely esophagogastroduodenoscopy in all cases of achalasia, even with seemingly normal imaging, to rule out pseudoachalasia related to malignancy.

## Linked entities

- **Diseases:** achalasia (MONDO:0008698), adenocarcinoma (MONDO:0004970), diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** weight loss (MESH:D015431), diabetic (MESH:D003920), Malignancy (MESH:D009369), vomiting (MESH:D014839), Pseudoachalasia of the Gastric Cardia (MESH:D004938), achalasia (MESH:D004931), abdominal pain (MESH:D015746)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10933952/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC10933952/full.md

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Source: https://tomesphere.com/paper/PMC10933952