# Causes of In-Hospital Death and Pharmaceutical Associations with Age of Death during a 10-Year Period (2011–2020) in Individuals with and without Diabetes at a Japanese Community General Hospital

## TL;DR

This study found that people with diabetes had similar lifespans as those without diabetes, but faced different causes of death and showed pharmaceutical associations with age of death.

## Contribution

The study reveals an inverse relationship between insulin secretagogues/insulin use and age of death in diabetic individuals.

## Key findings

- Diabetic individuals had higher rates of hepato-pancreatic cancer and cardio-renal failure as causes of death.
- Use of sulfonyl urea, glinides, and insulin was inversely associated with age of death.
- Pharmaceutical interventions in diabetic individuals were comprehensive and comparable to non-diabetic individuals.

## Abstract

Since diabetes and its complications have been thought to exaggerate cardiorenal disease, resulting in a short lifespan, we investigated causes of death and lifespans in individuals with and without diabetes at a Japanese community general hospital during the period from 2011 to 2020. Causes of death and age of death in individuals with and those without diabetes were compared, and associations between medications used and age of death were statistically analyzed. A total of 2326 deaths were recorded during the 10-year period. There was no significant difference between the mean ages of death in individuals with and those without diabetes. Diabetic individuals had higher rates of hepato-pancreatic cancer and cardio-renal failure as causes of death. The prescription rates of antihypertensives, antiplatelets, and statins in diabetic individuals were larger than those in non-diabetic individuals. Furthermore, the use of sulfonyl urea or glinides and insulin was independently and inversely associated with the age of death. In conclusion, individuals with diabetes were treated with comprehensive pharmaceutical interventions and had life spans comparable to those of individuals without diabetes. This study’s discovery of an inverse relationship between the use of insulin secretagogues or insulin and the age of death suggests that the prevention of life-threatening hypoglycemia is crucial for individuals with diabetes.