# Identification of Endothelial Cell Protein C Receptor by Urinary Proteomics as Novel Prognostic Marker in Non-Recovery Kidney Injury

## TL;DR

This study identifies a urinary protein that could predict non-recovery kidney injury in heart failure patients.

## Contribution

The study introduces endothelial cell protein C receptor (EPCR) as a novel prognostic marker for non-recovery acute kidney injury.

## Key findings

- EPCR was identified as a urinary marker for non-recovery acute kidney injury with high accuracy.
- The area under the receiver operating characteristics curve for EPCR was 0.776 ± 0.065.
- EPCR outperformed existing biomarkers in predicting non-recovery kidney injury in heart failure patients.

## Abstract

Acute kidney injury is a common and complex complication that has high morality and the risk for chronic kidney disease among survivors. The accuracy of current AKI biomarkers can be affected by water retention and diuretics. Therefore, we aimed to identify a urinary non-recovery marker of acute kidney injury in patients with acute decompensated heart failure. We used the isobaric tag for relative and absolute quantification technology to find a relevant marker protein that could divide patients into control, acute kidney injury with recovery, and acute kidney injury without recovery groups. An enzyme-linked immunosorbent assay of the endothelial cell protein C receptor (EPCR) was used to verify the results. We found that the EPCR was a usable marker for non-recovery renal failure in our setting with the area under the receiver operating characteristics 0.776 ± 0.065; 95%CI: 0.648–0.905, (p < 0.001). Further validation is needed to explore this possibility in different situations.