# Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome

## TL;DR

This study finds that technical factors during embryo transfer in IVF do not predict treatment success, with embryo quality and maternal age being more important.

## Contribution

The study demonstrates that commonly tracked embryo transfer parameters do not significantly influence IVF outcomes when adjusting for key covariates.

## Key findings

- Embryo transfer procedural parameters like catheter resistance or mucus presence do not predict IVF success.
- Embryo quality, number, and maternal age are significant predictors of clinical outcomes.
- Adjusting for covariates removes any statistical significance of procedural parameters.

## Abstract

Background: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were as follows: the presence of cervical mucus post catheter withdrawal, the presence of blood, catheter reload, the employment of a tenaculum and stylet, catheter resistance as experienced by the physician and patient discomfort. Results: When ET performance parameters were associated with clinical outcomes on a singular level, none of the ET parameters presented with any statistical significance. The evaluation of covariates indicated that the number and the quality of transferred embryos, as well as maternal age, exerted a statistically significant effect on clinical outcomes. In a multivariate analysis, only the presence of mucus along with significant catheter resistance presented with statistical significance; however, when adjusting for covariates, this combination showed no statistically significant effect on clinical outcomes. Conclusions: the results indicate that the time-consuming process of recording and analyzing ET performance parameters fails to offer any additional value in predicting the cycle’s outcome, while factors like embryo quality and number, as well as maternal age, seem to be the sole robust predictive factors of an IVF cycle.