# Successful Multidisciplinary Treatment, Including Atezolizumab Plus Bevacizumab Biological Therapy, for Multiple Hepatocellular Carcinomas Adjacent to Major Vessels: A Case Report

## TL;DR

A case report shows successful treatment of multiple liver cancers using a combination of biological therapy and less-invasive surgery.

## Contribution

Demonstrates the effectiveness of combining atezolizumab and bevacizumab with surgical approaches for multiple HCCs.

## Key findings

- Combination biological therapy followed by less-invasive surgery achieved long-term tumor control.
- Multidisciplinary treatment may be a preferred option for initially unresectable multiple HCCs.
- Underlying liver damage complicates treatment, but successful outcomes are possible with tailored approaches.

## Abstract

Multiple hepatocellular carcinomas (HCCs) are currently being treated with multimodal therapy that includes liver resection and local therapy. Although the necessity of multimodal therapy for multiple HCCs is evident, treating them is extremely difficult due to the complex nature of multiple HCCs and the frequent occurrence of underlying liver damage. We encountered a case in which long-term tumor control was achieved through multidisciplinary treatment, including atezolizumab plus bevacizumab combination biological therapy. As in the current case, less-invasive surgical resection combined with radiofrequency ablation after a combination of biological therapy may be one of the preferred options for the treatment of initially unresectable multiple HCCs.