# Mean Amplitude of Diurnal Variation of Sub-Foveal Choroidal Thickness among Adults with Healthy Eyes Visiting Outpatient Department of a Tertiary Eye Care Centre

## TL;DR

This study measured how much the choroid under the fovea changes in thickness throughout the day in healthy adults.

## Contribution

It reports the mean diurnal variation of sub-foveal choroidal thickness in a local population.

## Key findings

- The mean diurnal variation was 35.16±14.08 microns in 60 healthy eyes.
- Right eyes showed slightly higher variation than left eyes.
- Results were comparable to international studies on choroidal thickness.

## Abstract

The choroid, particularly the choroidal vasculature, plays an important role in the pathophysiology of various ocular diseases. Diurnal variation in the thickness of the choroid has been reported in previous studies. This study aimed to find the mean amplitude of diurnal variation of sub-foveal choroidal thickness among adults with healthy eyes visiting the outpatient Department of a tertiary eye care centre.

A descriptive cross-sectional study was conducted among adults with healthy eyes presenting to the outpatient Department of a tertiary eye care centre from 1 February 2023 to 3 June 2023 after obtaining ethical approval from the Institutional Review Committee. After a comprehensive medical eye examination, sub-foveal choroidal thickness measurement was performed using enhanced depth imaging optical coherence tomography at the baseline and subsequent interval afterwards. A convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.

Among 60 eyes, the mean amplitude of the diurnal variation of subfoveal choroidal thickness was 35.16±14.08 microns (31.59-38.72, 95% Confidence Interval). The mean amplitude for the right eye was 36.30±14.08 microns, and for the left eye, it was 34.23±14.08 microns.

The amplitude of diurnal variation of subfoveal choroidal thickness from this study was found to be similar to other studies done in international settings.