# MCSdb, a database of proteins residing in membrane contact sites

## TL;DR

MCSdb is a curated database of proteins found at membrane contact sites, helping researchers study how organelles communicate.

## Contribution

MCSdb is a new, manually curated database compiling MCS proteins and complexes from multiple species and organelles.

## Key findings

- MCSdb includes 7010 MCS protein entries and 263 complexes.
- The database covers 24 organelles and 44 MCSs across 11 species.
- MCSdb organizes data into categories to aid functional interpretation.

## Abstract

Organelles do not act as autonomous discrete units but rather as interconnected hubs that engage in extensive communication by forming close contacts called “membrane contact sites (MCSs)”. And many proteins have been identified as residing in MCS and playing important roles in maintaining and fulfilling specific functions within these microdomains. However, a comprehensive compilation of these MCS proteins is still lacking. Therefore, we developed MCSdb, a manually curated resource of MCS proteins and complexes from publications. MCSdb documents 7010 MCS protein entries and 263 complexes, involving 24 organelles and 44 MCSs across 11 species. Additionally, MCSdb orchestrates all data into different categories with multitudinous information for presenting MCS proteins. In summary, MCSdb provides a valuable resource for accelerating MCS functional interpretation and interorganelle communication deciphering.