# Cardiogenic Shock in a Patient With 4G/4G PAI Polymorphism and MTHFR A1298C Mutation

## TL;DR

A 75-year-old man with genetic mutations and peripheral artery disease developed cardiogenic shock from a heart attack despite no prior heart issues.

## Contribution

This case highlights a potential link between inherited thrombophilia and acute myocardial infarction leading to cardiogenic shock.

## Key findings

- A patient with 4G/4G PAI-1 polymorphism and MTHFR A1298C mutation developed cardiogenic shock from acute MI.
- The patient had no prior significant cardiac history but had peripheral artery disease.
- Inherited thrombophilia may contribute to acute MI in susceptible individuals.

## Abstract

Myocardial infarction (MI) remains a common cause of morbidity and mortality. Although many well-known risk factors exist, the association between inherited thrombophilia disorders and acute MI is not well described. Here, we present a case of a 75-year-old male with known 4G/4G PAI-1 polymorphism, methylenetetrahydrofolate reductase (MTHFR) mutation, and peripheral artery disease (PAD) post stent placement who presented with cardiogenic shock in the setting of acute MI with no prior significant cardiac history.