# Novel polymorphisms in CYP4A22 associated with susceptibility to coronary heart disease

## TL;DR

This study identifies genetic variations in the CYP4A22 gene linked to increased risk of coronary heart disease in a Chinese population.

## Contribution

The study reports novel associations between CYP4A22 polymorphisms and CHD susceptibility in the Chinese Han population.

## Key findings

- CYP4A22-rs12564525 and rs2056900 are significantly associated with CHD risk in overall and stratified analyses.
- The polymorphism rs2056900 is the best single-locus predictor of CHD susceptibility according to MDR analysis.
- False-positive report probability analysis confirms the significance of the observed associations.

## Abstract

Coronary heart disease (CHD) has become a worldwide public health problem. Genetic factors are considered important risk factors for CHD. The aim of this study was to explore the correlation between CYP4A22 gene polymorphism and CHD susceptibility in the Chinese Han population.

We used SNPStats online software to complete the association analysis among 962 volunteers. False-positive report probability analysis was used to confirm whether a positive result is noteworthy. Haploview software and SNPStats were used for haplotype analysis and linkage disequilibrium. Multi-factor dimensionality reduction was applied to evaluate the interaction between candidate SNPs.

In overall and some stratified analyses (male, age ≤ 60 years or CHD patients complicated with hypertension), CYP4A22-rs12564525 (overall, OR = 0.83, p-value is 0.042) and CYP4A22-rs2056900 (overall, OR = 1.22, p-value is 0.032) were associated with the risk of CHD. CYP4A22-4926581 was associated with increased CHD risk only in some stratified analyses. FPRP indicated that all positive results in our study are noteworthy findings. In addition, MDR showed that the single-locus model composed of rs2056900 is the best model for predicting susceptibility to CHD.

There are significant associations between susceptibility to CHD and CYP4A22 rs12564525, and rs2056900.

The online version contains supplementary material available at 10.1186/s12920-024-01833-7.