# The first Cyclospora cayetanensis lineage A genome from an isolate from Mexico

**Authors:** Monica Santin, Aleksey Molokin, Guadalupe E. Orozco-Mosqueda, Sonia Almeria, Jenny Maloney

PMC · DOI: 10.1186/s12864-024-10163-y · BMC Genomics · 2024-03-05

## TL;DR

This study reports the first genome of Cyclospora cayetanensis lineage A from Mexico, expanding understanding of the parasite's genetic diversity.

## Contribution

The first lineage A genome of C. cayetanensis from Mexico, adding to the limited global genomic data for this parasite.

## Key findings

- The genome of a C. cayetanensis isolate from Mexico was sequenced and classified as lineage A.
- This isolate represents a new lineage A genome from Mexico, contrasting with the previously known lineage B isolate from the same region.

## Abstract

Cyclospora cayetanensis is a protozoan parasite that causes intestinal illness in humans worldwide. Despite its global distribution, most genomic data for C. cayetanensis has been obtained from isolates collected in the United States, leaving genetic variability among globally distributed isolates underexplored.

In the present study, the genome of an isolate of C. cayetanensis obtained from a child with diarrhea living in Mexico was sequenced and assembled. Evaluation of the assembly using a lineage typing system recently developed by the Centers for Disease Control and Prevention revealed that this isolate is lineage A.

Given that the only other whole genome assembly available from Mexico was classified as lineage B, the data presented here represent an important step in expanding our knowledge of the diversity of C. cayetanensis isolates from Mexico at the genomic level.

The online version contains supplementary material available at 10.1186/s12864-024-10163-y.

## Linked entities

- **Diseases:** diarrhea (MONDO:0001673)
- **Species:** Cyclospora cayetanensis (taxon 88456)

## Full-text entities

- **Diseases:** diarrhea (MESH:D003967), intestinal illness (MESH:D007410)
- **Species:** Cyclospora cayetanensis (species) [taxon 88456], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10913667/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC10913667/full.md

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Source: https://tomesphere.com/paper/PMC10913667