Residual renal volume as a long-term independent predictive factor of developing chronic kidney disease after donor nephrectomy

TL;DR

This study finds that higher residual kidney volume after donation increases the risk of chronic kidney disease over time.

Contribution

The study identifies residual renal volume as a long-term independent predictor of CKD after kidney donation.

Findings

Residual renal volume over 50% increases CKD risk with a hazard ratio of 1.675.

Male gender is a strong risk factor for CKD with a hazard ratio of 4.013.

Older age slightly increases CKD risk with a hazard ratio of 1.107.

Abstract

To assess the long-term association between the residual renal volume and the progression of chronic kidney disease (CKD) in kidney donors following open or laparoscopic donor nephrectomy. A retrospective observational study involving 452 individuals who underwent open or laparoscopic donor nephrectomy at Ramathibodi Hospital, Bangkok, Thailand. The study spanned over a comprehensive 60-month monitoring period. Residual renal volume was determined through Computer Tomography. Patient characteristics, surgical techniques, donated kidney side, and estimated glomerular filtration rate (eGFR) were collected and analysed. In a multivariate analysis, a residual renal volume exceeding 50% of original volume is associated with an increased likelihood of developing CKD, with a hazard ratio (HR) of 1.675 (P < 0.05), and male gender has a hazard ratio (HR) of 4.013 (P < 0.001). Additionally, age is identified as a minor risk factor for developing CKD, with hazard ratio (HR) of 1.107 (P < 0.001). Higher residual renal volume, male gender, and older age were identified as independent risk factors for the development of CKD following open or laparoscopic donor nephrectomy during long-term follow-up.

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