# The P granule antibody KT3 recognizes epitopes in both PGL-1 and PGL-3

## TL;DR

This paper shows that the KT3 antibody binds to two similar proteins, PGL-1 and PGL-3, likely due to a shared region.

## Contribution

The study identifies that KT3 recognizes both PGL-1 and PGL-3 through a shared epitope in their disordered region.

## Key findings

- KT3 antibody recognizes both PGL-1 and PGL-3 proteins.
- The recognition is likely due to a shared epitope in the intrinsically disordered region of these proteins.

## Abstract

The KT3 antibody is a commercially available antibody that recognizes the P granule protein
PGL-3
(Takeda et al., 2008). Using immunostaining and western blotting of purified peptide fragments, we show that KT3 recognizes both
PGL-3
and its paralog
PGL-1
, likely through a shared epitope in the intrinsically disordered region.