# A Case of Idiopathic Multicentric Castleman’s Disease Diagnosed From Anemia and Renal Dysfunction on an Annual Check-Up

## TL;DR

A 34-year-old man was diagnosed with idiopathic multicentric Castleman's disease after showing symptoms of anemia and kidney issues during a routine check-up.

## Contribution

This case highlights the importance of considering iMCD in patients with unexplained anemia and renal dysfunction.

## Key findings

- The patient exhibited anemia, renal dysfunction, and elevated immunoglobulins without monoclonal patterns.
- Lymph node biopsy confirmed the diagnosis of idiopathic multicentric Castleman's disease.
- The case emphasizes the need for thorough evaluation in patients with atypical symptoms.

## Abstract

A 34-year-old man was referred to our hospital because of mild renal dysfunction and anemia. He had no specific preexisting medical conditions; his complaint was fatigue. Physical examination revealed several mobile, pinky head-sized (no tenderness) palpable lymph nodes on the bilateral neck. Blood biochemistry tests revealed anemia, renal dysfunction, increased inflammation, and a protein-albumin discrepancy. Immunological examination revealed polyclonal elevation of immunoglobulins (no shift in κ/λ ratio). A cervical lymph node biopsy was performed, and the pathological results showed numerous clusters of mature plasma cells (plasmacytic type), leading to the definitive diagnosis of idiopathic multicentric Castleman's disease (iMCD).