# A Case of Epstein-Barr Virus-Negative Post-transplant Lymphoproliferative Disorder in a Solid Organ Transplant Recipient With Untreated Chronic Hepatitis C

## TL;DR

This paper reports a rare case of EBV-negative PTLD in a transplant recipient with untreated chronic hepatitis C, suggesting a possible link between the two.

## Contribution

The paper presents a novel case linking untreated chronic hepatitis C with EBV-negative PTLD in a transplant recipient.

## Key findings

- An EBV-negative PTLD case was observed in a kidney-pancreas transplant recipient.
- The patient had untreated chronic hepatitis C, suggesting a potential association.
- Further studies are needed to confirm the link between HCV and EBV-negative PTLD.

## Abstract

Post-transplant lymphoproliferative disorder (PTLD) is one of the most common malignancies affecting solid organ transplant recipients. The disease is frequently associated with Epstein-Barr virus (EBV) infection (70% of cases) and cases are often delineated by EBV positivity status. The oncogenesis of EBV-positive PTLD is well-described in the literature; however, the etiology of the EBV-negative subtype is poorly understood. This report describes a case of EBV-negative PTLD developing in a combined kidney-pancreas transplant recipient with an incidental finding of untreated chronic hepatitis C virus (HCV). Our experience suggests an association between HCV and EBV-negative PTLD. Additional well-designed studies are needed to further investigate this association.