# Expression of concern: Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy

**Authors:** Michael A. Casasanta, G. M. Jonaid, Liam Kaylor, William Y. Luqiu, Maria J. Solares, Mariah L. Schroen, William J. Dearnaley, Jarad Wilson, Madeline J. Dukes, Deborah F. Kelly

PMC · DOI: 10.1039/d4nr90037e · 2024-02-14

## TL;DR

The paper expresses concern about the findings in a 2021 study on using microchip-based cryo-electron microscopy for determining low-molecular weight protein structures.

## Contribution

Raises concerns about the validity or reliability of the original study's results and conclusions.

## Key findings

- The original study's claims about the method's effectiveness may not be fully supported.
- There are potential issues with the data or interpretations presented in the original work.

## Abstract

Expression of concern for ‘Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy’ by Michael A. Casasanta et al., Nanoscale, 2021, 13, 7285–7293, https://doi.org/10.1039/D1NR00388G.

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Source: https://tomesphere.com/paper/PMC10903400