# New-Onset Intermittent Deceleration-Dependent Left Bundle Branch Block Following Induction of General Anesthesia in a Healthy Patient: A Case Report

**Authors:** Sengottaian Sivakumar, Mark J Young, Lazar Popilevsky

PMC · DOI: 10.7759/cureus.55211 · 2024-02-29

## TL;DR

A healthy patient developed a rare heart rhythm issue during anesthesia, highlighting the need for careful monitoring and drug use.

## Contribution

Highlights a novel case of deceleration-dependent left bundle branch block in a healthy patient under anesthesia.

## Key findings

- Transient left bundle branch block occurred at heart rates below 60 bpm during anesthesia.
- Condition resolved with heart rates above 90 bpm and was managed with glycopyrrolate.
- Postoperative tests showed normal heart function despite a small perfusion defect.

## Abstract

This case report aims to highlight an atypical presentation of deceleration-dependent aberrancy (DDA) following the induction of general anesthesia in a patient with no known cardiac history. It emphasizes the critical role of intraoperative monitoring and the potential effects of anesthetic agents on the cardiac conduction system.

A 46-year-old Hispanic male with no significant past medical or surgical history presented for surgical repair of a comminuted radial fracture. Following anesthesia induction with propofol, midazolam, and fentanyl, he developed a transient left bundle branch block (LBBB) exhibiting deceleration-dependent characteristics. Despite stable hemodynamics, the LBBB pattern appeared at heart rates below 60 beats per minute and resolved with heart rates above 90 beats per minute. This was managed intraoperatively with glycopyrrolate. Postoperative evaluations, including a 12-lead ECG, echocardiogram, and nuclear stress test, indicated normal biventricular function with a small to moderate reversible perfusion defect. The patient did not report cardiac symptoms postoperatively and did not prefer to undergo a coronary angiogram.

This report underscores the importance of recognizing rate-dependent LBBB as a potential intraoperative complication, even in patients without pre-existing cardiac conditions. The transient nature of DDA, influenced by anesthetic agents and managed through careful monitoring and pharmacological intervention, highlights the necessity for vigilance in perioperative settings. This case contributes to a growing body of evidence suggesting that anesthetic management may require tailored approaches for patients experiencing or at risk for conduction abnormalities.

This case illustrates the complexities of cardiac conduction disturbances such as DDA in the context of general anesthesia, serving as a reminder of the importance of thorough monitoring and the judicious use of rate-modifying drugs. It fosters a deeper understanding of the interaction between anesthesia and cardiac electrophysiology. Further research is needed to explore the mechanisms and management strategies for anesthetic-related cardiac conduction abnormalities.

## Linked entities

- **Chemicals:** propofol (PubChem CID 4943), midazolam (PubChem CID 4192), fentanyl (PubChem CID 3345), glycopyrrolate (PubChem CID 11693)

## Full-text entities

- **Diseases:** cardiac symptoms (MESH:D006331), cardiac conduction abnormalities (MESH:D006327), radial fracture (MESH:D011885), conduction abnormalities (MESH:D054537), cardiac conduction disturbances (MESH:C563984), LBBB (MESH:D002037)
- **Chemicals:** glycopyrrolate (MESH:D006024), fentanyl (MESH:D005283), midazolam (MESH:D008874), propofol (MESH:D015742)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10902872/full.md

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Source: https://tomesphere.com/paper/PMC10902872