Using cryopreserved allogeneic pericardium to repair congenital heart defects in children

TL;DR

This study shares a hospital's experience using frozen donor pericardium to repair heart defects in children, showing it can be used in various parts of the heart and circulation.

Contribution

The study provides a detailed single-center retrospective analysis of cryopreserved allogeneic pericardium use in pediatric heart surgeries.

Findings

Cryopreserved allogeneic pericardium was used in 382 children for congenital heart defect repairs.

Patches were implanted in both systemic and pulmonary circulations, as well as intracardiac and extracardiac positions.

There is no uniform strategy for selecting the optimal patch type for pediatric heart defect repairs.

Abstract

Patches prepared from autologous, allogeneic, or xenogeneic tissues are widely used in the repair of congenital heart defects in children. Since 2002, cryopreserved allogeneic pericardial patches have been prepared in our institution as an alternative to commercially available patches. This study retrospectively reviewed donor and patient data concerning cryopreservation time and the clinical use of the pericardium in 382 children who were operated on at a single center between 2004 and 2021. There were 177 donors: 98 males and 79 females. The median donor age was 13 years (range: 1 month to 53 years) and the median cryopreservation time was 72 days (range: 3–685). There were 382 pediatric patients: 224 males and 158 females. The median patient age was 1 month (range: 3 days to 17.8 years). The patches were used for primary surgeries in 228 patients and for reoperations in 154. The patches were implanted into the right heart or venous circulation in 209 patients, the left heart or arterial circulation in 246 patients, and both sides of the circulatory system in 73. Extracardiac patch implantation was performed in 339 patients, intracardiac in 79 patients, and both intracardiac and extracardiac in 36 patients. Our study presents a single-center experience in the use of cryopreserved allogeneic pericardium. The pericardium can be used on the systemic and pulmonary sides of the circulatory system, in either extracardiac or intracardiac positions. However, there is no uniform strategy for selecting the “patch of choice” for correcting congenital heart defects in children, especially since there are few studies comparing several types of patches.

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