# mSphere of Influence: Targeting bacterial signaling and metabolism to overcome antimicrobial resistance

## TL;DR

This article discusses how three influential papers shaped research on bacterial metabolism and antimicrobial resistance.

## Contribution

The paper highlights the impact of specific studies on understanding bacterial signaling and resistance mechanisms.

## Key findings

- c-di-AMP modulates Listeria monocytogenes metabolism to affect growth and resistance.
- Amino acid catabolism in Staphylococcus aureus is regulated by carbon catabolite repression.
- High-level β-lactam resistance in MRSA involves RNA polymerase changes and gene expression tuning.

## Abstract

Dr Merve Suzan Zeden works in the field of molecular bacteriology and antibiotic resistance. In this mSphere of Influence article, she reflects on how three papers, entitled “c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation,” “Amino acid catabolism in Staphylococcus aureus and the function of carbon catabolite repression,” and “Evolving MRSA: high-level β-lactam resistance in Staphylococcus aureus is associated with RNA polymerase alterations and fine tuning of gene expression,” made an impact on her work on bacterial metabolism and antimicrobial resistance and how it shaped her research in understanding the link in between.