# Management of Primary Infertility: A Comprehensive Approach With Magnetic-Activated Cell Sorting in an Asthenozoospermic Patient

## TL;DR

A couple with primary infertility successfully achieved pregnancy using magnetic-activated cell sorting to select sperm with reduced DNA fragmentation.

## Contribution

Demonstrates the effectiveness of MACS in managing asthenozoospermia with sperm DNA fragmentation.

## Key findings

- MACS improved sperm selection and led to successful blastocyst formation and pregnancy.
- The case highlights the potential of MACS in overcoming infertility due to sperm DNA fragmentation.
- Lifestyle factors remain important in comprehensive infertility management.

## Abstract

This report presents the cases of a 34-year-old male and a 29-year-old female who visited a fertility clinic and were experiencing primary infertility for the past three years. No previous medical history was identified in the couple. After a failed attempt of intrauterine insemination, the male partner was diagnosed with asthenozoospermia. A second attempt of intracytoplasmic sperm injection (ICSI) was performed which failed again. Subsequently, magnetic-activated cell sorting (MACS) technique was used as the sperm selection technique. The male patient’s sperms were selected through MACS before ICSI. After performing MACS, successful pregnancy was achieved, which resulted in the production of blastocysts and a positive beta-human chorionic gonadotropin test. This case report highlights the prospect of successful results, despite the presence of sperm DNA fragmentation, and a comprehensive strategy for managing infertility issues. Promoting knowledge of lifestyle factors and how they affect fertility remains an essential aspect of comprehensive infertility care.