# Unmasking the Enigma of Weil's Disease: A Case Report

**Authors:** Yusuf Yalcin, Ibrahim Kamel, Harinder Singh

PMC · DOI: 10.7759/cureus.55124 · Cureus · 2024-02-28

## TL;DR

A 37-year-old man with no typical risk factors was diagnosed with severe Weil's disease through clinical suspicion and treatment with doxycycline.

## Contribution

Highlights the importance of early recognition and diagnostic scoring systems in atypical Weil's disease cases.

## Key findings

- Patient showed rapid deterioration requiring ICU admission due to septic shock and respiratory failure.
- Empirical doxycycline treatment led to significant clinical improvement.
- Modified Faine's criteria aided in presumptive diagnosis despite inconclusive lab results.

## Abstract

We present the case of a 37-year-old male with Weil's disease, a severe form of leptospirosis, who presented without typical ecological risk factors. Initially manifesting as weakness, muscle aches, and fever, the patient rapidly deteriorated, necessitating ICU admission due to septic shock and respiratory failure. Despite initial diagnostic challenges, including normal initial imaging and inconclusive laboratory findings, a presumptive diagnosis of leptospirosis was made using Modified Faine's criteria. Empirical antibiotic treatment with doxycycline led to significant clinical improvement, highlighting the importance of early recognition and treatment in severe cases of leptospirosis. This case underscores the need for heightened clinical suspicion and the use of diagnostic scoring systems, even in atypical presentations, to facilitate timely intervention and improve patient outcomes.

## Linked entities

- **Chemicals:** doxycycline (PubChem CID 54671203)
- **Diseases:** Weil's disease (MONDO:0043004), leptospirosis (MONDO:0005825), respiratory failure (MONDO:0021113)

## Full-text entities

- **Diseases:** muscle aches (MESH:D063806), respiratory failure (MESH:D012131), leptospirosis (MESH:D007922), fever (MESH:D005334), septic shock (MESH:D012772), Weil's Disease (MESH:D014895), weakness (MESH:D018908)
- **Chemicals:** doxycycline (MESH:D004318)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10900174/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC10900174/full.md

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Source: https://tomesphere.com/paper/PMC10900174