# Nuxcell Neo® improves vaccine efficacy in antibody response

## TL;DR

This study shows that Nuxcell Neo® boosts antibody response in newborn mice after vaccination, without affecting their overall health.

## Contribution

The study demonstrates that Nuxcell Neo® enhances vaccine efficacy in newborns through improved antibody production.

## Key findings

- Nuxcell Neo® increased antibody concentration on days 14 and 21 post-vaccination in mice.
- Cytokine levels remained stable, indicating no adverse health effects from the treatment.
- The results support the use of Nuxcell Neo® as an effective supplement to improve vaccination outcomes.

## Abstract

Current vaccination protocols raise concerns about the efficacy of immunization. There is evidence that changes in the gut microbiota can impact immune response. The formation of the gut microbiota in newborns plays a crucial role in immunity. Probiotic bacteria and prebiotics present important health-promoting and immunomodulatory properties. Thus, we hypothesize that pro and prebiotic supplementation can improve the efficacy of vaccination in newborns. In this protocol, newborn mice were used and treated with a single-dose rabies vaccine combined with Nuxcell Neo® (2 g/animal/week) for 3 weeks. Samples were collected on days 7, 14, and 21 after vaccination for analysis of cytokines and concentration of circulating antibodies. Our results show an increased concentration of antibodies in animals vaccinated against rabies and simultaneously treated with Nuxcell Neo® on days 14 and 21 when compared to the group receiving only the vaccine. In the cytokine levels analysis, it was possible to observe that there weren't relevant and significant changes between the groups, which demonstrates that the health of the animal remains stable. The results of our study confirm the promising impact of the use of Nuxcell Neo® on the immune response after vaccination.