Research Progress of Granulocytic Myeloid-derived Suppressor Cells in Non-small Cell Lung Cancer

TL;DR

This paper reviews how granulocytic myeloid-derived suppressor cells (G-MDSCs) contribute to non-small cell lung cancer by suppressing immune responses and how targeting them could improve treatment.

Contribution

The paper provides an updated review on the role of G-MDSCs in non-small cell lung cancer and their potential as therapeutic targets.

Findings

G-MDSCs suppress T-cell activity through mechanisms like arginase-1 and reactive oxygen species.

Targeting G-MDSCs may improve cancer prognosis and immunotherapy outcomes in non-small cell lung cancer.

G-MDSCs are linked to tumor progression and immune microenvironment remodeling.

Abstract

粒细胞样髓源性抑制细胞（granulocytic myeloid-derived suppressor cells, G-MDSCs）是MDSCs的主要亚群之一，在多数癌症中广泛富集，通过表达精氨酸酶1（arginase-1, Arg-1）及活性氧（reactive oxygen species, ROS）等机制抑制淋巴T细胞杀伤功能，重塑肿瘤免疫微环境，促进肿瘤的发生发展。近年来，越来越多的研究发现G-MDSCs与非小细胞肺癌患者的预后和免疫治疗疗效具有显著相关性，使用特异性靶向G-MDSCs的募集、分化和功能的药物能够有效抑制肿瘤的进展。本文主要就G-MDSCs在非小细胞肺癌中的免疫抑制作用及其相关通路靶向药物的研究进展进行综述。