# Methicillin-Resistant Staphylococcus aureus Cellulitis Causing Meningitis From Hematogenous Dissemination: A Case Report

**Authors:** Omar M Masarweh, Suhail Saad-Omer, Michael Rohr, Neha Meda, Nicole Brenner

PMC · DOI: 10.7759/cureus.52969 · 2024-01-25

## TL;DR

A rare case of methicillin-resistant Staphylococcus aureus meningitis caused by bloodstream infection from a diabetic foot infection is reported and successfully treated.

## Contribution

This case report highlights a rare hematogenous route of methicillin-resistant Staphylococcus aureus causing meningitis.

## Key findings

- MRSA meningitis can result from hematogenous spread via bacteremia.
- A diabetic foot infection led to bloodstream infection and multiple complications including meningitis.
- Treatment with intravenous daptomycin and rifampin was successful.

## Abstract

Methicillin-resistant Staphylococcus aureus meningitis is commonly associated with surgical procedures that closely interact with the central nervous system; however, hematogenous spread via bacteremia is rarely reported. Here, we present a case of methicillin-resistant Staphylococcus aureus meningitis as a complication of a diabetic foot infection that disseminated into a bloodstream infection causing infective endocarditis, discitis, vertebral osteomyelitis, and meningitis that was successfully treated with intravenous daptomycin and rifampin.

## Linked entities

- **Chemicals:** daptomycin (PubChem CID 21585658), rifampin (PubChem CID 135398735)
- **Diseases:** infective endocarditis (MONDO:0000565), meningitis (MONDO:0021108)
- **Species:** Staphylococcus aureus (taxon 1280)

## Full-text entities

- **Diseases:** bloodstream infection (MESH:D018805), bacteremia (MESH:D016470), Cellulitis (MESH:D002481), diabetic foot infection (MESH:D017719), discitis (MESH:D015299), infective endocarditis (MESH:D004696), Meningitis (MESH:D008580), vertebral osteomyelitis (MESH:D010019)
- **Chemicals:** Methicillin (MESH:D008712), rifampin (MESH:D012293), daptomycin (MESH:D017576)
- **Species:** Staphylococcus aureus (species) [taxon 1280]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10894443/full.md

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Source: https://tomesphere.com/paper/PMC10894443