# Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants

## TL;DR

This review summarizes the roles of prefoldin proteins in plants, focusing on their structure, function in protein folding, and involvement in plant development and hormone responses.

## Contribution

The paper provides a comprehensive overview of plant-specific roles and conservation of prefoldin and its related proteins.

## Key findings

- Prefoldin subunits form hexameric complexes involved in protein folding and nuclear regulation in plants.
- Prefoldin plays a key role in phytohormone responses and global plant development.
- Emerging prefoldin-like subunits in plants suggest novel regulatory functions.

## Abstract

Prefoldins (PFDs) are ubiquitous co-chaperone proteins that originated in archaea during evolution and are present in all eukaryotes, including yeast, mammals, and plants. Typically, prefoldin subunits form hexameric PFD complex (PFDc) that, together with class II chaperonins, mediate the folding of nascent proteins, such as actin and tubulin. In addition to functioning as a co-chaperone in cytoplasm, prefoldin subunits are also localized in the nucleus, which is essential for transcription and post-transcription regulation. However, the specific and critical roles of prefoldins in plants have not been well summarized. In this review, we present an overview of plant prefoldin and its related proteins, summarize the structure of prefoldin/prefoldin-like complex (PFD/PFDLc), and analyze the versatile landscape by prefoldin subunits, from cytoplasm to nucleus regulation. We also focus the specific role of prefoldin-mediated phytohormone response and global plant development. Finally, we overview the emerging prefoldin-like (PFDL) subunits in plants and the novel roles in related processes, and discuss the next direction in further studies.