Ibuprofen-Loaded Silver Nanoparticle-Doped PVA Gels: Green Synthesis, In Vitro Cytotoxicity, and Antibacterial Analyses
Ezgi Altınay, Fatma Zehra Köse, Sezen Canım Ateş, Kadriye Kızılbey
TL;DR
This paper explores a green method to create hydrogel films containing silver nanoparticles and ibuprofen, which show effective drug release and antibacterial properties.
Contribution
The study introduces a cost-effective, eco-friendly synthesis of PVA hydrogels doped with silver nanoparticles for controlled drug delivery.
Findings
Hydrogel films with 5% and 10% PVA released 89% and 97% of ibuprofen by day 14.
Drug release kinetics followed the Korsmeyer–Peppas model.
The films exhibited in vitro cytotoxicity and antibacterial effects.
Abstract
In contrast to conventional drug delivery systems, controlled drug release systems employ distinct methodologies. These systems facilitate the release of active substances in predetermined quantities and for specified durations. Polymer hydrogels have gained prominence in controlled drug delivery because of their unique swelling–shrinkage behavior and ability to regulate drug release. In this investigation, films with a hydrogel structure were crafted using polyvinyl alcohol, a biocompatible polymer, and silver nanoparticles. Following characterization, ibuprofen was loaded into the hydrogels to evaluate their drug release capacity. The particle sizes of silver nanoparticles synthesized using a green approach were determined. This study comprehensively examined the structural properties, morphological features, mechanical strength, and cumulative release patterns of the prepared films.…
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Taxonomy
TopicsHydrogels: synthesis, properties, applications · Cancer Research and Treatment · Medical Research and Treatments