# Novel BRAF N581S mutation in mantle cell lymphoma

## TL;DR

This paper reports the first case of a BRAF mutation in mantle cell lymphoma, a type of blood cancer where such mutations were previously unknown.

## Contribution

The first documented case of a BRAF N581S mutation in mantle cell lymphoma.

## Key findings

- A 69-year-old female with mantle cell lymphoma was found to have a BRAF N581S mutation.
- This is the first reported case of any BRAF mutation in mantle cell lymphoma.
- The finding expands the understanding of genetic mutations in this type of lymphoma.

## Abstract

BRAF mutations are associated with a small number of hematologic malignancies, including hairy cell leukemia and histiocytic disorders. In addition, BRAF mutations have also been detected in low frequency in other B‐cell lymphomas, such as chronic lymphocytic leukemia and diffuse large B‐cell lymphoma, but never in mantle cell lymphoma (MCL). We present a case of a 69‐year‐old female with classic MCL harboring a BRAFN581S mutation. To our knowledge, this is the first reported case of any BRAF mutation in MCL.