# Ichthyosis Skin Changes in a Patient With Hereditary Hemochromatosis

## TL;DR

A patient with hereditary hemochromatosis developed ichthyosis-like skin changes, highlighting the need for physicians to recognize dermatologic symptoms of this condition.

## Contribution

This case report highlights the under-recognized association between ichthyosis and hereditary hemochromatosis.

## Key findings

- A 56-year-old male with HH presented with brown plate-like scales consistent with ichthyosis vulgaris.
- Ichthyosis in HH is not well documented, despite the high prevalence of skin manifestations in this disease.
- Physicians should be aware of dermatologic signs of hereditary hemochromatosis for early recognition.

## Abstract

Hereditary hemochromatosis (HH) is characterized by elevated iron absorption in the body, leading to iron accumulation with subsequent dysfunction and end-organ damage. While the progression of the disease can result in arthralgias, hepatomegaly, cardiomyopathies, and diabetes, over a third of HH patients present with cutaneous manifestations. We present the case of a 56-year-old male with HH who presented to dermatology with a rash and diffuse scaling. The patient exhibited brown plate-like scales clinically consistent with diffuse ichthyosis vulgaris. While ichthyosis has been seen in patients with idiopathic hemochromatosis, its association with HH is not well reported. Due to the high prevalence of cutaneous involvement in hereditary hemochromatosis, physicians should familiarize themselves with ichthyosis and the other dermatologic manifestations of this disease.