# Recent advances in the exploration and discovery of SARS-CoV-2 inhibitory peptides from edible animal proteins

## TL;DR

This paper reviews recent progress in finding peptides from animal proteins that can inhibit SARS-CoV-2, the virus causing COVID-19.

## Contribution

The paper introduces new methods like computer-aided design and phage display to identify and enhance antiviral peptides from animal sources.

## Key findings

- Animal-derived peptides show potential as safe and effective SARS-CoV-2 inhibitors.
- Computer-aided design and phage display are promising tools for discovering and optimizing these peptides.
- Investigating interactions with non-structural proteins could improve antiviral efficacy.

## Abstract

The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19), is spreading worldwide. Although the COVID-19 epidemic has passed its peak of transmission, the harm it has caused deserves our attention. Scientists are striving to develop medications that can effectively treat COVID-19 symptoms without causing any adverse reactions. SARS-CoV-2 inhibitory peptides derived from animal proteins have a wide range of functional activities in addition to safety. Identifying animal protein sources is crucial to obtaining SARS-CoV-2 inhibitory peptides from animal sources. This review aims to reveal the mechanisms of action of these peptides on SARS-CoV-2 and the possibility of animal proteins as a material source of SARS-CoV-2 inhibitory peptides. Also, it introduces the utilization of computer-aided design methods, phage display, and drug delivery strategies in the research on SARS-CoV-2 inhibitor peptides from animal proteins. In order to identify new antiviral peptides and boost their efficiency, we recommend investigating the interaction between SARS-CoV-2 inhibitory peptides from animal protein sources and non-structural proteins (Nsps) using a variety of technologies, including computer-aided drug approaches, phage display techniques, and drug delivery techniques. This article provides useful information for the development of novel anti-COVID-19 drugs.