# Development of Calvarial Bone Osteomyelitis in a Noonan Syndrome Patient Following Fronto-Orbital Advancement of Craniosynostosis: A Novel Technique of Treatment Using Povidone and Hydrogen Peroxide Solutions

## TL;DR

A child with Noonan syndrome developed a bone infection after cranial surgery and was treated with a new method using povidone and hydrogen peroxide solutions.

## Contribution

A novel treatment approach using povidone and hydrogen peroxide solutions for managing post-surgical bone infections in syndromic craniosynostosis.

## Key findings

- A pediatric patient with Noonan syndrome developed calvarial bone osteomyelitis after craniosynostosis surgery.
- A treatment using hydrogen peroxide and povidone solutions was effective in managing the bone infection.
- The case highlights the importance of tailored management and prophylactic antibiotics in syndromic craniosynostosis.

## Abstract

This is a case of a pediatric patient with Noonan syndrome (NS) and craniosynostosis who developed calvarial bone osteomyelitis following corrective surgery. Despite complications, such as postoperative bleeding and infections, including osteomyelitis, multidisciplinary management strategies were employed, including antibiotics, debridement, and novel use of hydrogen peroxide and povidone solutions due to bone thinning. The discussion highlights challenges in managing syndromic craniosynostosis, emphasizing the importance of tailored approaches and prophylactic antibiotics. The innovative treatment approach using hydrogen peroxide and povidone presents a potential alternative for bone infections and osteomyelitis post-cranial reconstruction, offering insights for future management strategies. Lessons learned regarding infection rates and novel treatment modalities contribute to evolving approaches in managing complications in syndromic craniosynostosis.