# Comparison of metabolic and neurological comorbidities in Asian patients with psoriasis and atopic dermatitis

## TL;DR

This study compares metabolic and neurological comorbidities in Asian patients with psoriasis and atopic dermatitis, finding higher risks in psoriasis patients.

## Contribution

The study provides new insights into subtype-specific comorbidities in psoriasis compared to atopic dermatitis in an Asian population.

## Key findings

- Psoriasis patients had higher odds of obesity, hypertension, diabetes, chronic kidney disease, and Parkinson's disease compared to AD patients.
- Plaque psoriasis was associated with increased risks of metabolic and neurological conditions, while guttate and pustular psoriasis showed unique associations with dementia and diabetes.
- Asian psoriasis patients, especially men and those aged ≥40 years, should be closely monitored for metabolic and neurological diseases.

## Abstract

Although various comorbidities have been noted to be associated with atopic dermatitis (AD) and psoriasis, few studies have compared comorbidities between the two diseases, and little is known about whether these comorbidities vary by the subtypes of psoriasis. In this study of 1:1 age- and sex-matched pair analysis between patients diagnosed with either psoriasis or AD at Asan Medical Center between 1991 and 2020, comorbidities, as determined by the International Classification of Diseases-10 codes, and likelihood ratios of metabolic and neurologic comorbidities in psoriasis compared with AD were studied using a logistic regression model. Among a total of 14,128 patients, the psoriasis group had higher odds of obesity (odds ratio [95% confidence interval]: 1.49 [1.34–1.66]), hypertension (1.14 [1.03–1.26]), diabetes mellitus (1.46 [1.29–1.66]), chronic kidney disease (1.59 [1.22–2.08]), and Parkinson's disease (2.1 [1.15–3.83]) than the AD group. Subgroup analysis revealed that patients with plaque psoriasis had higher odds of obesity (1.18 [1.05–1.33]), hypertension (1.18 [1.06–1.32]), diabetes mellitus (1.53 [1.34–1.75]), chronic kidney disease (1.66 [1.26–2.17]), and Parkinson’s disease (2.12 [1.16–3.88]) compared with AD. Meanwhile, guttate psoriasis was associated with higher odds of dementia (3.63 [1.06–12.40]) and patients with generalized pustular psoriasis showed higher odds of diabetes mellitus (5.42 [1.56–18.83]) compared with AD. In conclusion, Asian patients with all types of psoriasis should be closely monitored for the development of metabolic and neurologic diseases, especially men and those aged ≥ 40 years.