# A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

## TL;DR

This paper reports a rare case of a lymphoma-related condition causing dry gangrene in two limbs, successfully treated with a combination of therapies.

## Contribution

The novelty lies in documenting the first case of lymphoplasmacytic lymphoma associated with dry gangrene.

## Key findings

- A rare case of lymphoplasmacytic lymphoma with dry gangrene in both upper and lower extremities was identified.
- The patient was successfully treated with chemotherapy, steroids, plasmapheresis, and salvage surgery.
- This case highlights the potential for vascular complications in lymphoplasmacytic lymphoma patients.

## Abstract

Lymphoplasmacytic lymphoma (LPL) is an uncommon condition, accounting for only 2% of all non-Hodgkin's lymphoma cases. Individuals with LPL face the risk of vascular blockage when associated with type I cryoglobulinemia, leading to related symptoms. Until now, no instances of LPL with dry gangrene have been documented. However, we present a rare case involving LPL accompanied by dry gangrene in both the right upper extremity (RUE) and left lower extremity (LLE). The patient was effectively managed using a combination of chemotherapy, steroids, plasmapheresis, and salvage surgery.