# Esophageal Adenocarcinoma Presenting as an Isolated Brain Lesion 6 Years After Treatment

## TL;DR

A man developed brain cancer from esophageal adenocarcinoma six years after initial treatment, which is uncommon.

## Contribution

The case highlights a rare long-term recurrence of EAC as an isolated brain lesion.

## Key findings

- Intracranial metastasis from EAC occurred six years after initial diagnosis.
- Histological and genomic profiling confirmed the recurrence as EAC.
- Genomic profiling identified potential therapeutic biomarkers.

## Abstract

Intracranial metastasis is a rare sequela of esophageal adenocarcinoma (EAC), typically presenting within the first 2 years after primary tumor detection. Our patient is a 72-year-old man diagnosed with an EAC in 2015 and presented with recurrence of a distant solitary brain lesion approximately 6 years after the initial diagnosis. Histological diagnosis was confirmed as EAC with all relevant indicators. In addition, we used genomic profiling to detect biomarkers that can be useful in the future for therapies.