# Large Left Atrial Thrombus in a Patient With Severe Mitral Stenosis and Atrial Fibrillation Despite Anticoagulant Therapy: A Case Report

**Authors:** Silvio Nocco, Laura Concas, Marco Fei

PMC · DOI: 10.7759/cureus.52634 · 2024-01-20

## TL;DR

A patient with heart conditions developed a large blood clot despite taking blood thinners, showing the need for close monitoring and better treatment strategies.

## Contribution

Highlights the complexity of thrombus formation in patients with multiple cardiac risk factors despite anticoagulant therapy.

## Key findings

- A large left atrial thrombus was detected in a patient on anticoagulant therapy.
- Regular echocardiographic assessments are crucial for monitoring high-risk patients.
- Multidisciplinary management is needed for patients with atrial fibrillation and mitral stenosis.

## Abstract

This case report highlights a patient with atrial fibrillation, severe mitral stenosis, and left atrial dilatation who developed a large thrombus, despite being on anticoagulant therapy. The complexity of thrombus formation in patients with multiple risk factors is described, emphasising the need for regular echocardiographic assessments to detect and monitor thrombi, even in patients undergoing anticoagulant treatment. The interplay between atrial fibrillation, mitral stenosis, and left atrial dilatation contributes to thrombus formation, requiring a multidisciplinary approach to the management of these patients. Further research is needed to improve our understanding of the optimal treatment strategies for such cases. Timely identification and intervention are critical to mitigate the risk of thromboembolic complications in these high-risk patients.

## Linked entities

- **Diseases:** atrial fibrillation (MONDO:0004981), mitral stenosis (MONDO:0005852)

## Full-text entities

- **Diseases:** Mitral Stenosis (MESH:D008946), Atrial Fibrillation (MESH:D001281), thromboembolic complications (MESH:D013923), atrial dilatation (MESH:C563984), Left Atrial Thrombus (MESH:D013927)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10875398/full.md

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Source: https://tomesphere.com/paper/PMC10875398