# Novel Development of a Large Cerebral Cavernous Malformation in an Adolescent With a History of Familial Cerebral Cavernous Malformation Syndrome

## TL;DR

A 16-year-old girl with a family history of cerebral cavernous malformations developed a new large lesion in her brain during adolescence.

## Contribution

This case highlights the potential for new cavernoma development in adolescents with familial CCM syndrome.

## Key findings

- A large cavernoma was found in the right frontal lobe of a 16-year-old girl with familial CCM.
- The lesion was not present in an MRI scan from eight years earlier.
- The case shows that new cavernomas can develop later in adolescence.

## Abstract

Cerebral cavernous malformations (CCM) are capillary vascular malformations of the central nervous system (CNS). These lesions can be either familial or sporadic. We present a case of a 16-year-old girl with familial CCM syndrome who presented with a six-month history of chronic headaches. A magnetic resonance imaging (MRI) scan revealed a large cavernoma in the right frontal lobe that had not been present on a prior scan performed eight years earlier. This case presentation demonstrates the possibility of significant novel cavernoma development further into adolescence.