A298 HIGH MORTALITY NOTED AMONG PATIENTS ADMITTED WITH ALCOHOL ASSOCIATED HEPATITIS: A DESCRIPTIVE STUDY

TL;DR

This study finds that patients with alcohol-associated hepatitis face high mortality and frequent complications during hospital stays.

Contribution

The study provides new insights into mortality rates and complications among hospitalized patients with alcohol-associated hepatitis.

Findings

Approximately 44.3% of patients with alcohol-associated hepatitis experienced mortality, with 28.6% dying within 30 days.

33.3% of patients developed infectious complications, and 36.3% had gastrointestinal bleeding during admission.

The median hospital stay was 8.5 days, and 63% of patients received steroids during their admission.

Abstract

Alcohol associated hepatitis is a syndrome related to alcohol use disorder characterized by jaundice, malaise, decompensated liver disease, and coagulopathy. This is associated with bacterial infections, the development of chronic liver failure, and high short-term mortality. However, the rates at which these events occur is less understood, with a broad range of estimates reported.

To understand the demographic profile of those admitted with alcohol associated hepatitis assess its impact on resource utilization, complications in hospital, and mortality.

This study examined a subset of individuals with alcohol associated hepatitis who were admitted to the GI and Medicine Wards between 2010 and 2023.

70 encounters were identified and interpreted. The average age at admission was 48.3 ± 11.4 years old. 62.8% were male and 22% reported cannabis use. 54% had a previous reported history of alcohol use disorder. The average MELD-Na score at the time of admission was 25.9 ± 7.7.

The Median length of stay was 8.5 days (IQR 4.5,15). 63% were provided steroids in hospital and 33.3% developed infectious complications. 36.3% of patients had a GI bleed reported during admission. 4% of patients underwent a transplantation during follow-up. Approximately 44.3% experienced mortality with a 30-day mortality rate found to be 28.6%.

Alcohol associated hepatitis patients are prone to developing infections and bleeding during admission. This diagnosis also carries a high mortality rate, particularly within the first 30 days. Further studies examining the global impact of alcohol associated hepatitis should be considered.

Table 1: Baseline Demographics

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