# The Effects of Lithium Chloride Exposure on the Reproduction of Caenorhabditis elegans

**Authors:** George Hatzis, Olivia Rossi, Izabella Testiler, Grace Dobbins, Erica Homan

PMC · DOI: 10.17912/micropub.biology.000988 · 2024-02-01

## TL;DR

This study shows that lithium chloride negatively affects the reproduction of C. elegans, which could inform its impact on human health.

## Contribution

The study introduces new evidence on the reproductive toxicity of lithium chloride using C. elegans as a model organism.

## Key findings

- Lithium chloride exposure caused a statistically significant increase in egg retention in C. elegans.
- The results suggest lithium chloride may harm reproductive health in model organisms.

## Abstract

Caenorhabditis elegans 
(
C. elegans)
are model organisms that share similar anatomical structures to humans. By exploring the effects of lithium chloride (LiCl) on
C. elegans,
we can collect crucial data regarding the compound’s impact on patients taking psychiatric medications containing LiCl. Here we performed an egg retention assay on nematode populations to explore how LiCl can influence reproduction. We found a statistically significant difference in eggs retained between control and experimental groups, suggesting that LiCl has negative effects on reproductive health.

## Linked entities

- **Chemicals:** lithium chloride (PubChem CID 433294), LiCl (PubChem CID 433294)
- **Species:** Caenorhabditis elegans (taxon 6239)

## Full-text entities

- **Diseases:** psychiatric (MESH:D001523)
- **Chemicals:** LiCl (MESH:D018021)
- **Species:** Homo sapiens (human, species) [taxon 9606], C. elegans [taxon 328850], Caenorhabditis elegans (species) [taxon 6239]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC10870153/full.md

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Source: https://tomesphere.com/paper/PMC10870153