# Presence and Onset of Chronic Kidney Disease as a Factor Involved in the Poor Prognosis of Patients with Essential Thrombocythemia

## TL;DR

This study shows that chronic kidney disease worsens the prognosis of patients with essential thrombocythemia, emphasizing the need for regular kidney monitoring.

## Contribution

The study identifies both pre-existing and newly developed chronic kidney disease as significant risk factors for poor outcomes in essential thrombocythemia patients.

## Key findings

- 28.8% of essential thrombocythemia patients had chronic kidney disease at diagnosis.
- Chronic kidney disease presence was linked to a 3.75-fold higher risk of poor prognosis.
- Onset of chronic kidney disease during follow-up increased risk by 9.16-fold.

## Abstract

Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease, thrombosis, and all-cause death. However, few studies have examined the association between CKD and the prognosis of patients with essential thrombocythemia (ET). We collected ET patients who met the WHO classification 2017 and performed a retrospective clinical study to clarify the association between the presence and onset of CKD and prognosis. Of 73 patients who met the diagnostic criteria, 21 (28.8%) had CKD at the time of ET diagnosis. The age of patients with CKD was significantly higher, and a high proportion of these patients had the JAK2V617F gene mutation. The presence of CKD was a risk factor for the prognosis (hazard ratio (HR): 3.750, 95% confidence interval (CI): 1.196–11.760, P=0.023), and the survival curve was significantly poorer. Furthermore, we analyzed patients without CKD at the time of ET diagnosis using the onset of CKD as a time-dependent variable and identified the onset of CKD as a risk factor for the prognosis (HR: 9.155, 95% CI: 1.542–54.370, P=0.005). In patients with renal hypofunction at the time of ET diagnosis or those with a reduction in the kidney function during follow-up, strict renal function monitoring at regular intervals is necessary.