# Ir(iii)/Ag(i)-catalyzed directly C–H amidation of arenes with OH-free hydroxyamides as amidating agents

## TL;DR

This paper presents a new method for efficiently creating C–H amides using OH-free hydroxyamides without needing extra oxidants.

## Contribution

The use of OH-free hydroxyamides as amidating agents in Ir(iii)-catalyzed C–H amidation is novel and efficient.

## Key findings

- The reaction works with various functional groups and does not require external oxidants.
- A wide range of OH-free hydroxyamides, including non-conjugated ones, can be used effectively.
- The method produces N-(2-(1H-pyrazol-1-yl)alkyl)amide derivatives in good to excellent yields.

## Abstract

A versatile Ir(iii)-catalyzed C–H amidation of arenes by employing readily available and stable OH-free hydroxyamides as a novel amidation source. The reaction occurred with high efficiency and tolerance of a range of functional groups. A wide scope of aryl OH-free hydroxyzamides, including conjugated and challenging non-conjugated OH-free hydroxyzamides, were capable of this transformation and no addition of an external oxidant is required. This protocol provided a simple, straightforward and economic method to a variety N-(2-(1H-pyrazol-1-yl)alkyl)amide derivates with good to excellent yield. Mechanistic study demonstrated that reversible C–H bond functionalisation might be involved in this reaction.

A versatile Ir(iii)-catalyzed C–H amidation of arenes by employing readily available and stable OH-free hydroxyamides as a novel amidation source.