# Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report

## TL;DR

A 14-year-old girl with a rare skin condition called scleredema adultorum of Buschke was successfully treated with intravenous immunoglobulin and mycophenolate mofetil.

## Contribution

This case report presents a novel treatment approach for scleredema adultorum of Buschke using intravenous immunoglobulin and mycophenolate mofetil.

## Key findings

- The patient showed improvement after treatment with intravenous immunoglobulin and mycophenolate mofetil.
- No underlying malignancy or connective tissue disorders were found in the patient.
- Skin biopsy confirmed the diagnosis of scleredema adultorum of Buschke.

## Abstract

Scleredema adultorum of Buschke is a rare disease characterized by firm and non-pitting edema of the skin. The condition is rare with unknown etiology. Diagnosis is made on the basis of clinical findings and skin biopsy.

Here, we describe a 14-year-old Iranian girl presenting with non-pitting edema and woody thickening of the skin that progressed within a month. She was evaluated for possible underlying malignancy or connective tissue disorders, which were excluded by multiple laboratory workups. She underwent a skin biopsy which confirmed the diagnosis of scleredema, and she was successfully treated with intravenous immunoglobulin and mycophenolate mofetil.

While scleredema adultorum of Buschke is a rare disease with no definite treatment, our effort through this report was to highlight the possible benefits of treatment by intravenous immunoglobulin and mycophenolate mofetil.