# Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy

## TL;DR

This paper introduces a new nanoplatform for cancer treatment that combines photothermal therapy with reactive oxygen species generation to enhance tumor therapy.

## Contribution

The novel contribution is the rational design of Fe-ZIFs@CoP nanoplatforms that synergistically enhance tumor therapy through photothermal effects and ROS generation.

## Key findings

- Fe-ZIFs@CoP generates efficient ROS via the Fenton reaction and glutathione depletion.
- Photothermal effects from Fe-ZIFs@CoP enhance the Fenton reaction's performance for ROS production.
- The platform shows promise as an 'all-in-one' solution for cancer theranostics.

## Abstract

Metal-organic frameworks (MOFs), with biocompatible and bio-friendly properties, exhibit intriguing potential for the drug delivery system and imaging-guided synergistic cancer theranostics. Even though tremendous attention has been attracted on MOFs-based therapeutics, which play a crucial role in therapeutic drugs, gene, and biomedical agents delivery of cancer therapy, they are often explored as simple nanocarriers without further “intelligent” functions. Herein, Fe-doped MOFs with CoP nanoparticles loading were rationally designed and synthesized for photothermal enhanced reactive oxygen species (ROS)-mediated treatment. Fe-ZIFs@CoP could generate efficient ROS through the Fenton reaction while depleting glutathione for amplifying oxidative stress. Particularly, due to the photothermal effect of Fe-ZIFs@CoP, the hyperthermia generated by as-synthesized Fe-ZIFs@CoP facilitated the advanced performance of the Fenton effect for a high amount of ROS generation. The promising “all-in-one” synergistic MOFs platform herein reported provides some prospects for future directions in this area.