# A Rare Case of Uterine Blastomycosis and Its Management: A Case Report and Literature Review

**Authors:** Akbar Hussain, Fares Khater, Ali Raza, Huzefa Bhopalwala, Jonathan Piercy

PMC · DOI: 10.7759/cureus.52252 · Cureus · 2024-01-14

## TL;DR

This paper reports a rare case of uterine blastomycosis and discusses the challenges in diagnosing and managing this uncommon fungal infection.

## Contribution

The paper contributes a detailed case report and literature review on a rare form of Blastomyces infection with uterine involvement.

## Key findings

- Uterine blastomycosis is extremely rare, with fewer than 10 documented cases.
- Diagnostic challenges arise due to symptoms resembling common gynecological conditions.
- Multidisciplinary treatment involving antifungal agents like itraconazole is crucial.

## Abstract

The report delineates the rare occurrence of uterine blastomycosis, an atypical systemic presentation of Blastomyces dermatitidis infection prevalent in North America. Focused on a 51-year-old immunocompetent female displaying abdominal pain and irregular vaginal bleeding, it underscores the intricate diagnostic hurdles posed by symptoms mirroring common gynecological conditions. Despite fewer than 10 recorded cases, the rarity of uterine involvement highlights the imperative for heightened clinical suspicion. The multifaceted diagnostic strategy integrates risk factors, travel history, imaging, and histopathological examinations. Emphasizing a multidisciplinary treatment helmed by gynecologists, pathologists, and infectious disease specialists, the utilization of antifungal agents, notably itraconazole, is pivotal. Addressing the scarcity of literature and the condition's clinical resemblance to prevalent ailments, further research becomes paramount in devising tailored diagnostic and treatment protocols for uterine blastomycosis. This study enriches the existing literature by providing critical insights into a scarcely documented condition, contributing novel perspectives essential for clinical understanding and management strategies.

## Linked entities

- **Diseases:** blastomycosis (MONDO:0005672)
- **Species:** Blastomyces dermatitidis (taxon 5039)

## Full-text entities

- **Diseases:** infectious disease (MESH:D003141), gynecological conditions (MESH:D005831), abdominal pain (MESH:D015746), vaginal bleeding (MESH:D014592), Uterine Blastomycosis (MESH:D001759), Blastomyces dermatitidis infection (MESH:D010229)
- **Chemicals:** itraconazole (MESH:D017964)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10863517/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC10863517/full.md

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Source: https://tomesphere.com/paper/PMC10863517