# Serum albumin adjusted calcium and fluoride among type 2 diabetes mellitus patients

## TL;DR

The paper explores how calcium and fluoride levels are affected in patients with type 2 diabetes, focusing on the role of serum albumin in calcium regulation.

## Contribution

The study introduces the importance of adjusting calcium measurements for serum albumin in T2DM patients.

## Key findings

- Calcium homeostasis disruptions may contribute to insulin dysfunction in T2DM.
- Fluoride metabolism changes may occur due to impaired renal function in T2DM patients.
- Serum albumin levels significantly affect accurate calcium estimation in these patients.

## Abstract

The regulation of glucose-dependent insulin secretion in pancreatic β-cells relies on calcium concentration, making it a
calcium-dependent process. Disruptions in calcium homeostasis may contribute to insulin dysfunction and disturbances in glucose
homeostasis, potentially playing a role in the development of type 2 diabetes mellitus (T2DM). In T2DM patients, there may be changes in
fluoride metabolism due to impaired renal function. Measurement of serum albumin-adjusted calcium and is crucial since changes in
albumin levels can impact the accurate estimation of true calcium.