# Current status and perspectives of the quality system in histocompatibility laboratories in Poland

**Authors:** Izabela Uhrynowska-Tyszkiewicz, Katarzyna Bogunia-Kubik, Monika Baj-Krzyworzeka, Barbara Piątosa

PMC · DOI: 10.3389/fgene.2024.1322414 · 2024-01-26

## TL;DR

This paper discusses the current state and future directions of quality systems in histocompatibility labs in Poland, focusing on improving transplant success and patient outcomes.

## Contribution

The paper provides an analysis of the national supervision system and future prospects for histocompatibility laboratories in Poland.

## Key findings

- The national system of supervision and control for histocompatibility labs in Poland is described, including its development and organizational principles.
- Challenges faced by these labs include maintaining high-quality testing and participation in proficiency testing schemes.
- Suggestions for future improvements are based on input from the Polish histocompatibility community.

## Abstract

Allogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal—to maximize the recipients’ chance of survival and to improve their quality of life. One of the key elements of the process is to ensure high quality, accuracy, and reliability of histocompatibility testing. This manuscript presents: the development and organizational principles of the national system of supervision and control of histocompatibility laboratories in Poland, problems faced by these laboratories, availabe proficiency testing schemes, as well as suggestions and prospects for the future raised by members of the Polish histocompatibility community.

## Full-text entities

- **Genes:** HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) [NCBI Gene 3119] {aka CELIAC1, HLA-DQB, IDDM1}, HLA-A (major histocompatibility complex, class I, A) [NCBI Gene 3105] {aka HLAA}, HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) [NCBI Gene 3123] {aka DRB1, HLA-DR1B, HLA-DRB, SS1}, C1QA (complement C1q A chain) [NCBI Gene 712] {aka C1QD1}, HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) [NCBI Gene 3117] {aka CELIAC1, DQ-A1, DQA1, HLA-DQA, HLA-DQA1*}, HLA-B (major histocompatibility complex, class I, B) [NCBI Gene 3106] {aka AS, B-4901, HLAB}, HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) [NCBI Gene 3115] {aka DPB1, HLA-DP, HLA-DP1B, HLA-DPB}, ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)) [NCBI Gene 10058] {aka ABC, LAN, MTABC3, PRP, umat}
- **Diseases:** HcL (MESH:D007757), COVID-19 (MESH:D000086382)
- **Chemicals:** AQAP (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** S2 — Drosophila melanogaster (Fruit fly), Spontaneously immortalized cell line (CVCL_Z232), IU-T — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_4585)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10853346/full.md

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Source: https://tomesphere.com/paper/PMC10853346