# Life at the replication fork: A scientific and personal journey

**Authors:** Charles S. McHenry

PMC · DOI: 10.1016/j.jbc.2024.105658 · 2024-01-12

## Full-text entities

- **Genes:** Dhfr (dihydrofolate reductase) [NCBI Gene 13361] {aka 8430436I03Rik}, Tyms (thymidylate synthetase) [NCBI Gene 29261]
- **Diseases:** Cystic Fibrosis (MESH:D003550), confusion (MESH:D003221), Criticism (MESH:D016638), cytotoxicity (MESH:D064420), leukemia (MESH:D007938), Cancer (MESH:D009369), depression (MESH:D003866)
- **Chemicals:** phosphocellulose (MESH:C008881), 5-fluoro uracil (MESH:D005472), o-phenanthroline (MESH:C025205), ATP (MESH:D000255), glycerol (MESH:D005990), biotin (MESH:D001710), 6-tritiated FdUMP (-), '-Pi (MESH:D010716), Zn++ (MESH:D015032), nucleotide (MESH:D009711), amides (MESH:D000577), 5,10-methylene tetrahydrofolate (MESH:C013123), SDS (MESH:D012967), oxygen (MESH:D010100), urea (MESH:D014508), dGTP (MESH:C029603), polyacrylamide (MESH:C016679), dTTP (MESH:C024157), dATP (MESH:C026600), dTMP (MESH:D013938), Leucovorin (MESH:D002955), DMSO (MESH:D004121), diazirine (MESH:D003978), uracil (MESH:D014498), hydroxyapatite (MESH:D017886), poly dA (MESH:C015465), salt (MESH:D012492), methotrexate (MESH:D008727), FdUMP (MESH:D005468), fluorine (MESH:D005461), phosphate (MESH:D010710), folate (MESH:D005492), dUMP (MESH:C007267), peptide (MESH:D010455), ddGTP (MESH:C031709), flavins (MESH:D005415)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bacillus subtilis (species) [taxon 1423], Thermus thermophilus (species) [taxon 274], Mus musculus (house mouse, species) [taxon 10090], Escherichia coli (E. coli, species) [taxon 562]
- **Mutations:** K51E, D403E

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10850973/full.md

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Source: https://tomesphere.com/paper/PMC10850973