# Blastic Plasmacytoid Dendritic Cell Neoplasm: A Rare Entity in Clinical Practice

## TL;DR

This paper presents a case of a rare and aggressive blood cancer called BPDCN in an elderly woman, highlighting its diagnosis and treatment challenges.

## Contribution

The paper contributes a detailed case report emphasizing the importance of early detection and interdisciplinary care for BPDCN.

## Key findings

- BPDCN was diagnosed through bone marrow immunophenotyping in an 85-year-old patient.
- The case highlights the need for early detection and collaboration among specialists for better outcomes.
- Clinical features included fever, anorexia, and weight loss, which are non-specific and challenging for diagnosis.

## Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an exceedingly rare and aggressive hematologic malignancy. In the current World Health Organization classification, it is classified among histiocytic/dendritic cell neoplasms. This report describes the case of an 85-year-old female with a complex medical history, including rheumatoid arthritis, who presented with a one-month history of low-grade fever, anorexia, and unexplained weight loss. The diagnosis of BPDCN was confirmed following an immunophenotyping analysis of a bone marrow aspirate. With this report, the authors intend to shed some light on BPDCN's clinical presentation, diagnostic journey, therapeutic approaches, and patient outcomes, and denote the significance of early detection and interdisciplinary collaboration in enhancing patient care.