# Pulmonary interstitial glycogenosis in two neonates: Early recognition and use of corticosteroids

## TL;DR

This paper discusses two neonates with PIG and respiratory distress, showing how corticosteroids may affect their outcomes.

## Contribution

The study presents two distinct clinical cases of PIG and explores the variable response to corticosteroid treatment.

## Key findings

- PIG was diagnosed in two infants with congenital anomalies and respiratory distress.
- The infants showed differing clinical courses and responses to methylprednisolone therapy.
- The cases emphasize the need for better recognition of PIG and understanding of treatment benefits.

## Abstract

Pulmonary interstitial glycogenosis (PIG) is known to be associated with a wide variety of congenital conditions, though the extent to which PIG contributes to clinical presentation and outcomes in infants remains controversial. We describe two cases of infants with congenital anomalies and respiratory distress at birth who were diagnosed with PIG with differing clinical courses and response to methylprednisolone therapy. These cases highlight the importance of improved recognition of PIG and uncertainties about which patients may benefit from treatment.