# Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial

## TL;DR

A clinical trial compared orange peel extract to Alveogyl for palatal healing, finding the extract effective in reducing pain and improving healing.

## Contribution

This study introduces orange peel polymethoxy-flavonoids as a novel palatal dressing material with clinical benefits.

## Key findings

- OPMF group showed lowest pain scores in week one and consumed fewer analgesic pills.
- Healing process in OPMF group was faster compared to placebo at 1 and 2 weeks.
- OPMF demonstrated potential for hemostasis, pain relief, and wound healing in palatal dressing.

## Abstract

This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in group I received OPMF; group II received Alveogyl; and group III received placebo dough material. The visual analog scale (VAS) pain score in group I showed the lowest value in week one without a significant difference. In week 2, there was a substantial decrease in pain in group I compared to group III. Week 4 showed reduced pain scores in all groups without significant differences. The results of the number of analgesic pills revealed, after 1 week, the lowest number of pills consumed in group I, with a considerable difference compared to group III. Healing process results showed that group I had the highest healing values in each interval, with a significant difference between group I and group III at 1 and 2 weeks. Color matching parameter showed slight differences between the groups’ readings in favor of group I in all intervals without a statistically significant difference. The results suggest OPMF as a palatal dressing material that facilitates hemostasis, pain relief, and palatal wound healing.