# Lupus-Induced Accelerated Heart Failure in a Young African American Female: Cardiovascular and Systemic Complications of Noncompliance to Maintenance Therapy and the Social Determinants of Cardiovascular Disease

**Authors:** Ikpechukwu J Okorie, Edmund Appiah-Kubi, Philipa Owusu-Antwi, Evans Takyi, Derek Ugwendum, Annmarie Fernando, Muhammed Atere, Jay Nfonoyim

PMC · DOI: 10.7759/cureus.51819 · Cureus · 2024-01-07

## TL;DR

A young African American woman with lupus developed severe heart failure due to not following her treatment, highlighting the risks of noncompliance and social factors in heart disease.

## Contribution

This case emphasizes the rare occurrence of lupus-induced cardiomyopathy and the impact of social determinants on cardiovascular outcomes.

## Key findings

- Lupus-induced cardiomyopathy led to rapid structural and functional heart failure in a young patient.
- Noncompliance with maintenance therapy accelerated fatal cardiac complications.
- Social determinants significantly influenced the patient's cardiovascular prognosis.

## Abstract

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder characterized by dysregulations of the immune system with intermittent and remitting symptoms. SLE affects multiple organs and systems, including the cardiovascular system. This condition is associated with an increased risk of cardiovascular disease, particularly in younger patients. Our case report describes a patient who rapidly developed structural, functional, and electrophysiological cardiac abnormalities due to lupus-induced cardiomyopathy. The accelerating cardiac events were the result of medication noncompliance. Myocarditis and other potentially fatal cardiac complications associated with SLE have been the subject of numerous studies. This presentation appears to be the first to emphasize the rarity of lupus-induced cardiomyopathy, the importance of treatment adherence, the adverse cardiac effects of targeted therapeutic interventions, and the influence of social determinants of cardiovascular health on a patient's prognosis.

## Linked entities

- **Diseases:** Systemic lupus erythematosus (MONDO:0007915), heart failure (MONDO:0005252), myocarditis (MONDO:0004496)

## Full-text entities

- **Diseases:** cardiomyopathy (MESH:D009202), Myocarditis (MESH:D009205), autoimmune inflammatory disorder (MESH:D007249), Heart Failure (MESH:D006333), cardiac (MESH:D006331), cardiac abnormalities (MESH:D018376), Lupus (MESH:D008180), Cardiovascular Disease (MESH:D002318)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC10847065/full.md

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10847065/full.md

## References

36 references — full list in the complete paper: https://tomesphere.com/paper/PMC10847065/full.md

---
Source: https://tomesphere.com/paper/PMC10847065