# Disseminated Superficial Porokeratosis: A Case Report

## TL;DR

This case report describes a rare skin condition called disseminated superficial porokeratosis in a 45-year-old woman, highlighting its diagnosis, treatment, and the importance of long-term care.

## Contribution

The paper presents a detailed case of disseminated superficial porokeratosis with multimodal treatment and emphasizes diagnostic and management insights.

## Key findings

- Histopathological confirmation of coronoid lamellae confirmed the diagnosis.
- Multimodal treatment including topical and systemic therapies led to satisfactory clinical outcomes.
- Long-term follow-up and patient education are crucial for managing the condition and improving quality of life.

## Abstract

Disseminated superficial porokeratosis is a rare dermatological disorder characterized by annular keratotic lesions, presenting diagnostic challenges due to its variable clinical manifestations. The pathogenesis involves genetic predisposition and environmental factors, with mutations in the mevalonate pathway implicated. Despite its benign nature, this condition significantly impacts patients' quality of life, necessitating accurate diagnosis and effective therapeutic strategies. We present the case of a 45-year-old female with a three-year history of annular plaques on sun-exposed areas progressing to involve multiple body regions. The characteristic histopathological finding of coronoid lamellae confirmed the diagnosis of disseminated superficial porokeratosis. Treatment involved a multimodal approach, including topical corticosteroids, calcineurin inhibitors, and systemic retinoids, resulting in satisfactory clinical outcomes. Long-term follow-up emphasized the need for ongoing disease monitoring and patient education regarding sun protection. The presented case underscores the importance of recognizing characteristic histopathological features for accurate diagnosis and highlights the significance of long-term follow-up, disease monitoring, and patient education to optimize outcomes and enhance overall quality of life.